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DFO, the most widely used iron chelator approved by the FDA, inhibits lipid peroxide chelation by inhibiting the Fenton reaction, and one study found that DFO effectively protects neurons by increasing the expression of hypoxia-inducible factor 1 (HIF-1

Shikonin triggers GSDME-mediated pyroptosis in tumours by regulating autophagy via the ROSMAPK14/p38 axis

In future research, these findings could be further explored to develop drugs that target the Nrf2-mediated antioxidant defence system

Proton pump inhibitors are associated with hypersensitivity reactions to drugs in hospitalized patients: a nested case-control in a retrospective cohort study

however, patients who are candidates for expectant, medical or surgical management should be individualized, and especially if they are going to be taken to surgery, an excellent mapping of fibroids prior to surgical intervention is recommended