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Although zebularine and 5AC are equally potent as small oligodeoxynucleotides, the potency of zebularine is approximately one-tenth of that of 5AC in inducing demethylation when used as a single agent ( 4.1.3 Guadecitabine Guadecitabine (SGI-110), also a second-generation DNA methyltransferase inhibitor, is a dinucleotide molecule linked by a phosphodiester bond between DAC and deoxyguanosine ( Loss of DNMT1 expression results in prolonged activation and promoter DNA demethylation of tumor-testis antigens, including the melanoma-associated antigen (MAGEA)-1 and MAGEA3 genes in human fibroblasts

doi: 10.1016/j.neurobiolaging.2014.10.029 127 OgawaK.YamadaT.TsujiokaY.TaguchiJ.TakahashiM.TsuboiY.et al

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Peripheral neuropathy is also a common complication of chemotherapy which places an upper limit on the dosages used (Pachman et al 2011)

Mechanisms tagging senescent red blood cells for clearance in healthy humans