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By blocking ME2 to lower NADPH levels and adding BSO (GSH synthesis inhibitor) to enhance the ROS effect in concert, the oxidative defense barrier of AML cells was successfully broken (113, 157)

Thus, oxidative damage in depression and anxiety disorders can aect the amygdala and hippocampus (Salim, 2017), among other brain structures, reduce neurogenesis (Hassan et al., 2014;van Velzen et al., 2017), and contribute to cognitive dysfunction (Duy et al., 2014)

Consequently, HIF-1 has been shown to upregulate NQO1 expression in response to stressful events, such as hypoxia

10.1152/physrev.00010.2018 28 BhattiJ

Introducing a second agent with a different mechanism can restart progress by circumventing the specific adaptations the body made in response to the first compound