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Symptoms, which typically emerge before six months of age, include failure to thrive, decreased appetite, lethargy, anemia, and GI issues like diarrhea

Handle under appropriate laboratory conditions

It has been shown to decrease homocysteine levels, which is associated with the development of dementia and Alzheimers disease

Its substrate site-targeting mechanism inhibiting NNMT at the nicotinamide binding site provides selectivity over related methyltransferases and other enzymes in the NAD salvage pathway, making it a precise tool compound for studying NNMT-specific enzymatic activity in controlled laboratory systems

Recommended dosing ranges for each tier can be found under the applicable medication dropdown below