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Exposure to oxygen, heat, and light can degrade its active form, reducing efficacy

In this review, we describe the role of ROS and mitochondrial damage in the major pathological changes that occur in RA, summarize the drugs targeting ROS or mitochondria for RA treatment, and suggest their relatively weakly studied but value-rich directions in RA

Chen H-JC, Lin W-P, Chiu S-D, Fan C-H (2014) Multistage mass spectrometric analysis of human hemoglobin glutathionylation: correlation with cigarette smoking

Melatonin counteracts necroptosis and pulmonary edema in cadmium-induced chronic lung injury through the inhibition of angiotensin II

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