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The primary source of ROS leading to chondrocyte death and exacerbating inflammatory reactions, thereby aggravating articular cartilage degradation, is mitochondrial dysfunction

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showed that supplementation with lutein (10 mg), zeaxanthin (2 mg), and meso-zeaxanthin (10 mg) for 12 months improved cognitive abilities and episodic memory in participants [26]

Synthesis of these lipids is catalyzed by Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4), whose expression is therefore a prerequisite for cellular ferroptosis sensitivity [20]

Particularly important is the major human DME CYP3A4 [111]