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The homeostasis and renewal of the intestinal epithelium involve stem cell proliferation at the base of the crypt bottom, cell population expansion in the middle of the villus, terminal differentiation in the upper villus and senescent cell extrusion at the villus tip (Yang et al

These mutations occurring in FAD highlight the genetic basis of tau-associated neurodegenerative pathology and central involvement in the pathogenesis of AD (Lansdall, 2014)

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Continued research efforts are expected to lead to broader adoption of metformin in clinical practice