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The role of autophagy in resistance to targeted therapies

Rosenbaum M, Godmsith R, et al

Kido A, Miyake M, Akagi T, Ikeda HO, Kameda T, Suda K, Hasegawa T, Hiragi S, Yoshida S, Tsujikawa A, Tamura H, Kawakami K

(B) SGC7901-ATF4 cells were transfected with scrambled siRNA (SCR) or SIRT1 siRNA (siSIRT1)

We observed a consistent increase in sensitivity, or reduced IC 50 value, for mutant cells treated with doxycycline but not parental OVCAR5 cells, indicating that induction of mutant p53 sensitized cells to APR-246 (Fig