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More recent studies presented conflicting evidence whether SCs are required for muscle hypertrophy [124,125], indicating the importance of careful evaluation and selection of appropriate animal model to address the in vivo contribution of SCs to muscle hypertrophy and the role of IGF-1

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Transfecting the expression plasmid of HIF-1 into liver cancer cells, or treating with CoCl 2 to increase the protein level of HIF-1 in the cells, both will lead to an increase in the mRNA expression levels of Clock and Bmal1