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In atherosclerotic plaque, increased matrix metalloproteinase expression and activity triggered by oxidative stress lead to its rupture and consequent thrombosis (He and Zuo, 2015)

Simultaneously, the fluorescence staining results of SOX9 revealed the distribution of Sertoli cells in chicken testes, and compared with that in mouse testes, more chicken testicular Sertoli cells were distributed in the seminiferous tubules (Fig

Results showed that only the highest concentration triggered a slight barrier integrity loss on day 4

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Moreover, mechanistic studies show that bronchoconstriction in ASMC causes mechanical stress on the airway epithelium, triggering the release of epithelial growth factors like TGF- and EGF, which leads to airway remodeling in asthma, as illustrated in Figure 11 (109, 112)