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coli supplemented with glucose also led to an increase in the AGE carboxymethyl-lysine (CML) as detected by ELISA (Figure 1c)

To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)

Interestingly, epidemiological studies corroborated this observation in humans as well (Myers and Davidson, 2000), reinforcing the idea that the developing CNS is most susceptible to the deleterious effects of MeHg

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A recent report revealed that ferroptosis inducers, such as RSL3 and erastin, induced the ASK1-p38 MAPK pathway activation downstream of lipid ROS in A549 cells [43]