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Many patients see changes within 12 weeks, but timelines vary

Thus, we know that the likelihood of developing pre-eclampsia (equivalent to B in Figure 1) increases with certain pre-conditions (first pregnancy with the father, existing diabetes, maternal age, BMI, blood pressure at first visit, infection, etc.) (e.g., refs

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10.1046/j.1365-2982.2001.00287.x 58 LuceyM

Both have shown efficacy in different models, and the choice depends on the specific research question