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in the de-nitrosylation process two vicinal cysteines in the protein become oxidized while the nitrosothiol is reduced producing free nitroxyl (HNO) or NO, then Trx is efficiently reduced by the NADPH-dependent activity of Trx reductase enzyme

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In its discovery-to-proof-of-concept work, it activated both receptors in vitro , improved glucose-dependent insulin secretion and glucose tolerance in animals, and in early human studies lowered fasting glucose and body weight