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Standard medical dosing for confirmed deficiency typically involves an initial loading phase followed by maintenance

10.1016/j.fertnstert.2004.06.056

Early studies on LC using a human hepatocellular carcinoma cell line (Hep G2 cells) revealed that both slc1a5 promoter activity and the protein expression of ASCT2 were dependent on the presence of Gln

The absence of a safety mechanism or switch further increases the risk of severe or fatal side effects, such as tumor lysis syndrome and cytokine release syndrome (Jureczek et al., 2019)

In addition, epithelial carcinoma cells exposed to cisplatin, 5-flourouracil and docetaxel demonstrate a drug resistance phenotype that has been shown by oxidative damage adaptation through Nrf2 upregulation and autophagy-mediated clearance of toxic p62 aggregates (58)