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351 Similar fatal outcomes occur in mice lacking SESTRINs or autophagy-related genes

This offers new insights into combination strategies involving targeted drugs (such as anti-EGFR or BCL-2 inhibitors) with cuproptosis inducers, which are particularly applicable to drug-resistant tumors with hyperactive mitochondrial metabolism, though further clinical validation is required

GPX3 is upregulated in total tissue lysates from IPF patients Western Blot analysis and ELISA, using independently derived antibodies, showed upregulation of GPX3 protein levels in total lung lysates from IPF patients, but not from end-stage HP patients, relative to healthy donor control (Fig

10.1161/ATVBAHA.121.317239 85

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