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dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

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Clinical trials demonstrate unprecedented weight loss of up to 22.5% of body weight over 72 weeks , rivaling the outcomes of bariatric surgery, alongside a 2.02.4% reduction in HbA1c , achieving glycemic control unparalleled in current diabetes treatments ( 1, 2, 3 )

Comparison of BDNF-boosting peptides The following comparison helps illustrate the relative strengths and research maturity of each compound