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The inclusion of a hexahistidine-tag in sdAbs (and other recombinant proteins) initially serves purification purposes (57, 58), however, it also offers the advantage of easy radiolabeling with 99m Tc through tricarbonyl chemistry ( 99m Tc proves to be an ideal radioisotope for the design of bimodal sdAb tracers given its wide availability via 99 Mo/ 99m Tc-generators, its half-life aligning well with the blood half-life of sdAbs (49), its relatively low radiation energy profile enhancing the safety for both patients and personnel, and its routine use for gamma-probing in the operating theatre, meaning all hardware, protocols and experience is available

doi:10.1002/jbm.a.34420 128

Hsp70 is believed to bind multiple receptor molecules on DC membranes including Toll-like receptor 4 (TLR4), TLR2, CD14, CD91, and CD40

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Guillain-Barr syndrome and COVID-19 vaccination: a systematic review and meta-analysis