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What are the tissue-specific dosing protocols

The nasal mucosa is highly vascularized, allowing absorption directly into circulation, and some evidence suggests nasal administration may provide more direct central nervous system access via the olfactory pathway

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123,124 Novel regulators of bone formation related to the Wnt/-catenin signalling pathway Regulation of bone formation and differentiation by Wnt players : Doxycycline induces Wnt7b expression in an osteoblast cell line, and the high expression of Wnt7b in aged bone promotes the formation of trabecular and endosteal bone and increases the mineral density of the bone callus during fracture healing

Taken together, these results suggest that CPP-CAND inhibited the FOXO4-p53 interaction in the nucleus, which enabled the extranuclear transport of p53 and selectively induced apoptosis in senescent cells