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Hui Shi, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In vitro, cysteine derivatives act by breaking disulphide bridges between macromolecules, which leads to a reduction in mucus viscosity.(1) However, at higher doses (1200mg), acetylcysteine also acts as an antioxidant through complex mechanisms which can combat conditions of oxidative stress

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Meanwhile, the activity of glutathione reductase, a sensitive marker for riboflavin status, was decreased significantly when the cells were cultured in the riboflavin deficient media (Fig