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Of these overweight patients, more than 62% were noted to have acanthosis nigricans and it was particularly prominent in the Hispanic and African American children (1)

Activation triggers eumelanin synthesis via the cAMP/PKA pathway, increasing dark pigment production

Cancer Research Maresca, V., et al

Keep the bottle in its original packaging away from direct light

Clinicians should carefully assess all nails for atypical features that may indicate a developing periungual melanoma and prompting a referral to a dermatologist for evaluation (Box 7-1)