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NK012 is a polymeric micelle-based nanotherapeutic encapsulating 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan, engineered to improve pharmacokinetics and tumor-selective delivery via the EPR effect

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Role in systemic acquired resistance

45 The trial also showed KarXT triggered a 3.5-point benefit in the reduction of positive schizophrenia symptoms like hallucinations and delusions

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