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10.1038/s41584-023-00947-z 125 PradeepC

Maturation of nave T cells depends on autophagy to reduce mitochondrial and ER contents through mitophagy and reticulophagy, respectively (143, 145, 146)

Patients with TTC19 mutations often present with early psychomotor retardation, followed by progressive neurological decline and poor prognosis (89)

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With mutagenesis studies, we propose an acyl-modification driven ghrelin-binding model, in which the binding of octanoyl group in cavity II orients the N-terminus of ghrelin to cavity I, and leads to the initiation of signal transduction