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They increase oxidative stress, damage cellular structures, and promote the fibrotic changes associated with permanent hair loss

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The enhanced penetration achieved through microneedling allows for effective results with less frequent treatments compared to topical application alone

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All experiments were conducted in a buffer solution containing 20 mM HEPES (pH 7.0), 150 mM NaCl, 1 mM dithiothreitol (DTT), and 5% dimethyl sulfoxide (DMSO)