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During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

Using a 50% probability cutoff, the AHEAD Score achieved a specificity of 61.5% (107 out of 174 non-cases correctly identified) and a sensitivity of 63.3% (19 out of 30 cases correctly identified)

Products marketed outside approved channels are not subject to the same quality and safety controls as approved medications, which increases variability and risk

Se is a component of about 25 enzymes including the GSH-Px family, thioredoxin reductases and selenoprotein P which provide antioxidant protection against ROS-driven cancer initiation and promotion, as well as some others (Zachara et al., 2006

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