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The cornea is vulnerable to damage from UV-light exposure, physical wounds, and bacterial or fungal infections because of its special placement at the outermost surface of the eye globe [272]

Some experts have cautioned against their use, pointing to concerns over incorrect dosing, potential contaminants, unintended biological effects and the lack of human testing

However, under certain circumstances such as during an Autoimmune response, neutrophils can be triggered to release ROS extracellularly causing damage to host tissues, modification of host proteins, lipids and DNA and dysregulation of oxidative homeostasis

[PubMed] [Elsevier] Chen Y, Yang Y, Miller ML, Shen D, Shertzer HG, Stringer KF, Wang B, Schneider SN, Nebert DW, Dalton TP (May 2007)

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