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But even this apparently benign role may have a darker side as substance P immunoreactive astrocytes have been identified in MS plaques (Kostyk et al., 1989), and a requirement for substance P/NK-1R interactions has been reported for the maintenance of chronic inflammation in experimental autoimmune encephalomyelitis (EAE) mouse models of MS (Reinke et al., 2006)

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Mol Cancer Ther 14(1):193201 de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I et al (2010) Prednisone plus Cabazitaxel or Mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial

Springer, Dordrecht, pp 181236 Klutsch JG, Shamoun SF, Erbilgin N (2017) Drought stress leads to systemic induced susceptibility to a nectrotrophic fungus associated with mountain pine beetle in Pinus banksiana seedlings