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Cochrane Database Syst Rev, 2003;CD004031, doi:10.1002/14651858.CD004031

Transcription factor binding prediction analysis for differentially expressed genes suggested that SIRT3-induced transcriptional changes in aged HSCs was influenced by transcription factors that are involved in the establishment of chromatin accessibility at inflammation-trained loci, such as NF-B, FOS, JUN, GATA1, ATF family members, CREB1, EGR1 and STAT family members (Extended Data Fig

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However, the relative contribution of each pathway to overall efficacy in topical applications requires further clarification through mechanistic studies