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A novel homozygous disruptive mutation in the SRD5A2-gene in a partially virilized patient with 5alpha-reductase deficiency

Biogerontology 21(2):231244

We thank the Humanized Mouse Platform: Patient Derived Tumor, Gut Microbiota Transplantation and Gene Modification Service at the National Core Facility for Biopharmaceuticals, National Laboratory Animal Center, Taiwan for providing the germ-free mouse facilities

Histone alterations Modifications of histone negatively or in a positive fashion affect the binding of regulatory factors to DNA, resulting in diminished or escalated activity pertinent to gene and expression

This is when our body is in a glycogen depleted state which allows the body to be in lipogenesis and without the circulation of blood sugar, inhibits muscle breakdown