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In preclinical studies, the efficacy of HMCD-drug conjugates is generally characterised in vitro , and mouse xenograft models are typically used to establish the biodistribution of the HMCD-conjugates in different organs

Future Research Directions Despite significant progress, several critical questions remain to be addressed

The final fate of intracellular meningococci is largely unknown, but it has been found that GPB1, mediating the initial assembly of GBP platform on cytosolic Gram-negative intracellular bacteria, and GBP3, a component of the GBPs recruited to the platform for caspase-4 activation, selectively lyse F

The SOCS box of SPSB1 enhances the ubiquitination and degradation of TRII, keeping its levels low [163]

integrated with valorization of industrial wastewater under two-stage LED light illumination strategy