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Consistently, Reactome (REAC) analysis revealed that CHL-upregulated proteins were significantly enriched in the innate immune system ( p adjusted = 3.1E-12), complement cascade ( p adjusted = 6.6E-07) and antimicrobial peptides ( p adjusted = 3.5E-08)

Results MnO 2 NPs were synthesized by reducing potassium permanganate (KMnO 4 ) to manganese dioxide (MnO 2 ) in the presence of biocompatible polymers (i.e., PVP and PAA)

doi: 10.1002/advs.201500053 141 NagayamaAVidulaNEllisenLBardiaA

doi: 10.1007/s12393-024-09394-2 131

234 MTAP is located in the periphery of the tumor suppressor cyclin-dependent kinase inhibitor 2 A (CDNK2A), and the co-deletion of the two genes occurs in ~15% of cancers and results in a highly aggressive tumor with a poor prognosis