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The current body of evidence is predominantly preclinical, limiting the extrapolation of therapeutic claims to clinical practice

For example, Ju et al

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Honeys polyphenolic constituents, in particular caffeic acid phenethyl ester (CAPE), gallic acid, and chrysin, exert potent anti-inflammatory effects, targeting these molecular pathways ( Table 3 )

Results: scRNA-seq analysis revealed that a subset of MDMs expressed tissue restoration-related genes ( Arg1 , Il10 , and matrix metalloproteases), referred to as restorative MDMs, which highly expressed Slc7a11 encoding the cystine/glutamate antiporter (xCT) in both mouse and human