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While pro-inflammatory mediators can induce neutrophils to generate glycolytic intermediates from non-glucose substrates via gluconeogenesis (a compensatory mechanism of metabolic reprogramming), this compensation fails to reverse functional deficits

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Other environmental exposures, which have been related to DNA methylation, such as exposure to tobacco smoke [13-17] and air pollution [18], are out of the focus of the present review, as tobacco smoke and air pollution are mixtures of different types of chemicals rather than individual groups of compounds

(November 1995), "Abnormalities of carnitine metabolism in chronic fatigue syndrome", European Journal of Neurology , 2 (5): 425428, doi:10.1111/j.1468-1331.1995.tb00151.x, ISSN 1351-5101, PMID 24283722 Tomas, Cara