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Liver and Brain Dysfunction When oxygen levels drop below 2%, the liver reduces hemoglobin production, leading to hypoxia, impaired energy production, and increased red blood cell (RBC) destruction.76 Chronic liver damage is linked to processing RBC byproducts like hemoglobin, iron, and cholesterol, which accumulate in organs like the liver, pancreas, and bone marrow, disrupting metabolism

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These patients should be considered for specific treatment (discussed below )

Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial

J Bioenerg Biomembr 41(6):469472