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They are further categorized into the condensed form of proanthocyanidins, in which the main structural unit is the phenolic flavan-3-ol nucleus and hexahydroxydiphenoyl and galloyl ester and their derivatives, ellagitannins and gallotannins (Clifford and Scalbert, 2000)

Each of these creates a different problem

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Clinical features reflect the effects of slowed organ function and decreased metabolic rate

To address this, providers sometimes recommend a daily multi-vitamin, especially if the children: Have self-restricted diets Follow a specific diet (for example, if a child is consuming a diet free of casein, a multi-vitamin may be necessary to ensure adequate vitamin D and calcium intake.) Have chronic diarrhea, constipation, or gastrointestinal inflammation The use of mega-dose vitamins and nutritional supplements beyond a multi-vitamin are not fully supported for routine use