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RAGE is highly upregulated in metastatic and aggressive breast, ovarian, and pancreatic cancer, acting as a promotor of the progression of premalignant precursors to invasive carcinoma 88,89

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Patients were initially administered with the starting dose of 500 mg/day of curcumin and if no apparent toxicity occurred, increments in dosage were done step-wise in the order of 1000, 2000, 4000, 8000 to 12000 mg/day