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This work was supported by the grants from National Key R&D Program of China (2019YFA0802502), National Natural Science Foundation of China (81925008 and 32130047), Project supported by Shanghai Municipal Science and Technology Major Project, and Open Project Program of Metabolic Vascular Diseases Key Laboratory of Sichuan Province (2022MVDKL-K2) to YL

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On EDD10, based on cell viability data, selected concentrations of 1 M IKE, 50 M 5-FU, and their combination were applied to a 6 mm-diameter filter paper using the wafer technique (50 L) and placed near the tumor