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Definition of cell senescence Although research on cell senescence lasts for decades, until recently, the field reached a consensus on the definition of cell senescence, that is, a type of cell state that can be stimulated by multiple stress signals throughout the life cycle and is characterized by cell cycle arrest, senescence-associated secretory phenotype (SASP), and dysregulated metabolism and macromolecular damage 1 (Fig

Aldrink, J., Shaffiey, S., Wright, S

This dual nature allows it to act in every part of the cell, including the cytoplasm and cellular membranes

Although our in vivo data robustly demonstrate multi-system recovery, the intricate cellular and molecular crosstalk underlying these effects invites further elucidation through reductionist in vitro models

Original Investigation