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These have a place, but their effect is constrained by one fundamental problem: most peptides dont cross the skin barrier in meaningful amounts

Importantly, WT forms of both SOD1 and TDP-43 form inclusions following BSO treatment

kim S, Quoc QL, Park H, Shin YS

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Although the secretory pathway promotes oxidative folding through the oxidoreductase family, a large proportion of glutathione in the ER lumen is found as mixed disulphides with proteins (Bass et al , 2004)