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Vernoux et al., 2000

Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, is a specific GSDME inhibitor and highly effective against cholestatic liver failure

[7] The effect size is modest relative to established diabetes drugs, but it does suggest the supplement is not pharmacologically inert in this population

3 In addition, the amino acid's breakdown product histamine also plays an essential role in the body, and too low histamine levels also prove to be problematic for health