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In fact, GSH metabolism impairment has been associated with several diseases such as cancer, kwashiorkor, seizure, Alzheimers and Parkinsons disease, liver disease, cystic fibrosis, sickle cell anaemia, acquired immunodeficiency disease syndrome (AIDS), heart attack, stroke, diabetes [8,14,15], several mitochondrial disorders [16], Niemann Pick type C disease [17] and progressive multiple sclerosis [18,19]

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2 Nonantimicrobial sulfonamides include carbonic anhydrase inhibitors, selective cyclooxygenase-2 inhibitors, loop diuretics, sulfonylureas, thiazide diuretics, triptans, and other agents