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The theory described in the peptide literature is that a GHRH analog (signal one) and a ghrelin-receptor agonist (signal two) act in a complementary, even synergistic, way producing a larger GH pulse together than either pathway alone, because the pituitary carries co-receptors for both inputs

They were briefly given category 2 status on this list, which makes it far more difficult for pharmacies to compound them legally

However, side effects can occur, and long-term safety data are limited

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Ipamorelin Therapy and Growth Hormone Levels Ipamorelin therapy is designed to increase growth hormone levels, which naturally decline with age