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2018) and the mitochondrial inner membranes (Huang et al

doi:10.1186/s13018-021-02268-x 555. Iyer AS, Chapoval SP

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Furthermore, IL-1 stimulates RMCs to secrete higher amounts of IL-8, an important activator and recruiter of leukocytes, by activating p38 MAPK and extracellular regulated protein kinase (ERK)-1/2,thus amplifying diabetic retinal inflammation ( Under the stimulation of inflammation, the expression of cell adhesion molecules and chemokines such as intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) are also upregulated in RMCs, thus promoting the migration and adhesion of leukocytes to the retinal vessel wall, ultimately disrupting vascular permeability (Taghavi et al., 2019)