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Moreover, MTX-treated animals (group 4) demonstrated moderate records of tubular degeneration with significant loss of luminal border integrity of proximal and distal convoluted tubules (red arrows) with occasional luminal detached epithelial cells (black arrow), marked congested and dilatation of glomerular tuft capillaries (black arrow head), mild periglomerular and interstitial mononuclear inflammatory cells infiltrates were observed (red arrow head) accompanied with mild interstitial and perivascular fibrosis in Massons trichrome-stained sections

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Chronic disease occurs when cells fail to heal or contain inflammation, and a toxic repeating loop of incomplete recovery and re-injury occurs

Deficiencies in these nutrients can tilt the immune system toward chronic inflammation and impair resilience to stressors, further fueling autoimmune processes

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntingtons disease