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Furthermore, researchers often deplete endogenous GSH levels in cell models, using inhibitors of its synthesis like buthionine sulfoximine (BSO), to investigate the role of the glutathione system in mediating the cytotoxicity of specific drugs or environmental toxins

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The FDA Advisory Committee has voted in favor of many changes thought to improve safety and decrease toxicity, yet the FDA has not yet taken action

CG-B, AR-O, CC-R wrote the original draft

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