glutathione with electrophile Electrophiles modulate reductase activity via alkylation and upregulation of glutathione biosynthesis is made oxidative stress analysis Selective covalent targeting of GPX4

Selective covalent targeting of GPX4 using masked nitrile oxide electrophiles Nature Chemical Biology Endogenous Glutathione Conjugates: Occurrence and Biological Functions Pharmacological Reviews Beyond detoxification: Pleiotropic functions of multiple glutathione S transferase isoforms protect mice against a toxic electrophile PLOS One Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis ScienceDirect Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology

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