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COVID-19 causes necrotic damage to the lungs, and the resulting cytokine storm can also spread to multiple organs through the circulatory system, resulting in cell necrosis of various organs and leading to MODS (50)

Carvedilol confers ferroptosis resistance in HL-1 cells by upregulating GPX4, FTH1, and FTL1 and inducing metabolic remodeling under hypoxia/reoxygenation