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Abbreviations PsO: Psoriasis IMQ: Imiquimod PUVA: Psoralen + Ultraviolet A HaCaT: Human adult low calcium high temperature (immortalized keratinocyte cell line) PASI: Psoriasis area and severity index NF-B: Nuclear Factor kappa-light-chain-enhancer of activated B cells JAK: Janus kinase STAT: Signal transducer and activator of transcription STAT3: Signal transducer and activator of transcription 3 IL: Interleukin TNF-: Tumor necrosis factor-alpha TNF: Tumor necrosis factor IFN-: Interferon-gamma EGCG: Epigallocatechin gallate ROS: Reactive oxygen species Nrf2: Nuclear factor erythroid 2related factor 2 UV: Ultraviolet BALB/c: Mouse strain EE: Entrapment efficiency NLC: Nanostructured lipid carrier SLN: Solid lipid nanoparticles PVA: Polyvinyl alcohol MS: Multiple sclerosis AA: Arachidonic acid SK: Skin MA: Methacrylic acid SA: Stearic acid References Morrone A, DellAnna ML, Cristaudo A, Wubayehu T, Godefay H, Barnabas GA, et al

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Considering the important role of macrophages in iron metabolism regulation, macrophage was chosen as the source of EVs in the present study