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M-cells take up large antigens, macromolecular complexes, particulates, and proteins such as ferritin and peroxidase and also intact viruses, bacteria, and protozoa through a specific and regulated process termed receptor-mediated endocytosis in which cell-surface receptors such as GP2 recognize specific antigens expressed on microorganisms that initiate transit through the cell, exocytosis, and engulfment by phagocytic subepithelial dendritic cells (Fig

This complex is not affected by pH, temperature, organic Extreme factors such as solvents

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2021;17:e2102046

Davies CR, Wohlgemuth F, Young T, Violet J, Dickinson M, Sanders J-W, Vallieres C, Avery SV