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Cells were pre-incubated with H2O2 (0.2 mM, a-vi), 5 g/mL Lps (a-v), and 2.5 g/mL Lps (a-vi) for 2 h, and then incubated with LJ-GSH (10 M) for 30 min

Unlike MOTS-c, which has a short half-life and requires frequent dosing, 5-amino-1MQ has a longer duration of action, allowing once-daily administration

Furthermore, abnormalities in the GABA system are associated with an increase in repetitive behaviors, disrupted information processing, and a heightened vulnerability to seizures, all due to impaired inhibitory signaling and altered network excitability

Much of what we know comes from animal and laboratory research

MOTS-c (Mitochondrial-Derived Peptide) is a naturally occurring 16-amino acid peptide encoded by the mitochondrial genome (specifically the 12S rRNA gene)