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As reported for genomic DNA, mtDNA is also amenable to chemical modifications, namely DNA methylation

T cells accumulate in the intestine before arthritis onset To investigate cellular intestinal alterations that precede the onset of arthritis in more detail, we analyzed T-cell subsets in the intestine at different time points during the CIA time course

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It can also emerge during times when progesterone levels are manipulated, such as during In Vitro Fertilization (IVF)